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生化與生醫工程研究所
國立臺北科技大學 生化與生醫工程研究所
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20120523 生技所專題討論演講, 賴鴻政醫師, 三總婦產科主任
發佈日期 : 2012-05-09

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時間:2012/05/23 (三) 下午 1:10 至 3:00

地點:生物科技館303教室

演講題目:甲基化DNA作為癌症生物標記之開發

DNA METHYLATION IN GYNECOLOGICAL CANCERS: BIOMARKER DEVELOPMENT AND IMPLICATIONS FOR PERSONALIZED MEDICINE

講員: 賴鴻政醫師, 三總婦產科主任

摘要:

Cervical cancer is one of the top leading causes of morbidity and mortality in women, especially in developing countries. Although early diagnosis is possible, a cytology-based screening is resource-demanding, and the performance is not satisfactory. Missing diagnosis, as well as, overtreatment of precancerous lesions is common. Radical surgery for invasive cancers may increase the survival but severely compromise the life quality. A less extensive surgery is worthwhile for selected patients with invasive cancers as long as risk factors for local invasion or distant metastasis are informative. The development of DNA methylation as a biomarker for an improving cervical cancer screening, the triage of mildly abnormal cytology or biopsy results, or the selection of a more conservative surgery is possible. Meanwhile, ovarian cancer is the most common lethal woman cancer. Although origins are heterogenous, most patients receive the same treatments majorly surgery, followed by platinum-based chemotherapy. Recurrence is common and adjuvant chemotherapy is empiric. Target therapy has not been proven effective in ovarian cancer yet. There is an urgent need of biomarkers for the stratification of patients with responses to chemotherapeutics. The advancement of epigenetics has revealed the promise of an epigenetic therapy. Demethylation agents have been approved for clinical application in some cancers. The treatment of ovarian cancer patients may be individualized regarding to different methylation profiles, especially using epigenetic drugs. The translation of epigenome researches to clinical applications may provide a new perspective of genomic medicine in the near future.

[Keywords] : DNA methylation; cervical cancer; ovarian cancer

 

 

 

 

 

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